Calmodulin dependence of presynaptic metabotropic glutamate receptor signaling.
basic_science · Level V
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Abstract
Glutamatergic neurotransmission is controlled by presynaptic metabotropic glutamate receptors (mGluRs). A subdomain in the intracellular carboxyl-terminal tail of group III mGluRs binds calmodulin and heterotrimeric guanosine triphosphate-binding protein (G protein) betagamma subunits in a mutually exclusive manner. Mutations interfering with calmodulin binding and calmodulin antagonists inhibit G protein-mediated modulation of ionic currents by mGluR 7. Calmodulin antagonists also prevent inhibition of excitatory neurotransmission via presynaptic mGluRs. These results reveal a novel mechanism of presynaptic modulation in which Ca(2+)-calmodulin is required to release G protein betagamma subunits from the C-tail of group III mGluRs in order to mediate glutamatergic autoinhibition.
Medical subject headings
- Calmodulin
- GTP-Binding Proteins
- Glutamic Acid
- Potassium Channels, Inwardly Rectifying
- Receptors, Metabotropic Glutamate
- Synaptic Transmission