Immunoassay for urothelial cancers that detects DNA replication protein Mcm5 in urine.
basic_science · Level V
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Abstract
Cancer-screening tests for internal organs are severely constrained by low specificity or sensitivity, cost, and morbidity. We report a non-invasive immunofluorometric assay for detection of urothelial cancers based on ectopic expression of the DNA replication protein Mcm5.
Medical subject headings
- Carcinoma, Transitional Cell
- Cell Cycle Proteins
- Fluorescent Antibody Technique, Indirect
- Urinary Bladder Neoplasms