Effect of citric acid on the nucleation of hydroxyapatite in a simulated body fluid.
basic_science · Level V
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Abstract
The role of citric acid in a simulated body fluid (SBF) was examined with the main focus on its induction ability of hydroxyapatite (HAp) nucleation on a bioinert collagen membrane. Collagen membranes were soaked in the SBF with citric acid concentrations in the range of 0-4 mM; then, carbonate-containing HAp crystals grew within a limited range, i.e., 0.3-2 mM. The results were explained in terms of chemical interaction among calcium ion, citric acid and collagen membrane, especially strong chelation ability of citric acid with the calcium ion.
Medical subject headings
- Citric Acid
- Collagen
- Durapatite
- Materials Testing
- Membranes, Artificial