Antineutrophil cytoplasmic antibodies in systemic lupus erythematosus in childhood.
case_series · Level IV
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Abstract
Antineutrophil cytoplasmic antibodies (ANCA) have been found in up to 25% of adults with systemic lupus erythematosus (SLE) and in 69% of affected children. We investigated ANCA and antibodies to myeloperoxidase (MPO) in 50 children with SLE. ANCA in serum were measured by indirect immunofluorescence and antibodies to MPO by ELISA. ANCA were found in 8 (7 perinuclear ANCA, 1 cytoplasmic ANCA) of the 50 sera tested (16%). All the 8 ANCA positive patients were also positive for anti-MPO antibodies. No association with vasculitis or specific organ involvement was observed. Our results in children are roughly similar to those reported for adults.
Medical subject headings
- Antibodies, Antineutrophil Cytoplasmic
- Lupus Erythematosus, Systemic