The dimensions of the protein import channels in the outer and inner mitochondrial membranes.
basic_science · Level V
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- Record sourced from PubMed, PMID 10557277.
- Also identified by PMC identifier 23904.
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Abstract
Most mitochondrial proteins are imported into mitochondria through transmembrane channels composed largely, and perhaps exclusively, of proteins. We have determined the effective internal diameter of the protein import channel in the mitochondrial outer membrane to be between 20 A and 26 A during translocation. The diameter of the import channel in the inner membrane is smaller than the diameter of the outer membrane import channel. These results were obtained by measuring the effect of rigid steric bulk introduced into precursor proteins on import.
Medical subject headings
- Intracellular Membranes
- Mitochondria
- Proteins