Class II-independent generation of CD4 memory T cells from effectors.
basic_science · Level V
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- Record sourced from PubMed, PMID 10558997.
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Abstract
The factors required for the generation of memory CD4 T cells remain unclear, and whether there is a continuing requirement for antigen stimulation is critical to design of vaccine strategies. CD4 effectors generated in vitro from naïve CD4 T cells of mice efficiently gave rise to small resting memory cells after transfer to class II-deficient hosts, indicating no requirement for further antigen or class II recognition.
Medical subject headings
- Histocompatibility Antigens Class II
- Immunologic Memory
- T-Lymphocyte Subsets
- Th1 Cells
- Th2 Cells