Neonatal end-stage renal failure associated with maternal ingestion of cyclo-oxygenase-type-1 selective inhibitor nimesulide as tocolytic.
case_report · Level V
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Abstract
Cyclo-oxygenase-type-2 (COX-2) enzyme is fundamental for nephrogenesis, upregulated on fetal membranes and myometrium at parturition. Fetal COX-2 inhibition, due to maternal nimesulide assumption, can be responsible for neonatal chronic renal failure.
Medical subject headings
- Cyclooxygenase Inhibitors
- Kidney Failure, Chronic
- Obstetric Labor, Premature
- Prenatal Exposure Delayed Effects
- Sulfonamides