Reporting bias in retrospective ascertainment of drug-induced embryopathy.
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Abstract
The rate of congenital malformations after first-trimester exposure to itraconazole was four times higher when ascertained retrospectively than prospectively (13.0 vs 3.2%, p=0.006). Reporting bias in retrospective studies should be acknowledged in interpretation of such data.
Medical subject headings
- Abnormalities, Drug-Induced
- Antifungal Agents
- Data Collection
- Itraconazole