Clinical applications of angiogenic growth factors and their inhibitors.
review · Level V
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Abstract
Promoting the formation of new collateral vessels in ischemic tissues using angiogenic growth factors (therapeutic angiogenesis) is a an exciting frontier of cardiovascular medicine. Conversely, inhibition of the action of key regulators of angiogenesis, such as VEGF, constitutes a promising approach for the treatment of solid tumors and intraocular neovascular syndromes. These concepts are being tested now in clinical trials.
Medical subject headings
- Endothelial Growth Factors
- Growth Inhibitors
- Lymphokines
- Neovascularization, Physiologic