Reversal of virus-induced systemic shock and respiratory failure by blockade of the lymphotoxin pathway.
basic_science · Level V
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Abstract
At present, little is known about the pathogenesis of acute virus-induced shock and pulmonary failure. A chief impediment in understanding the underlying disease mechanisms and developing treatment strategies has been the lack of a suitable animal model. This study describes a mouse model of virus-induced systemic shock and respiratory distress, and shows that blockade of the lymphotoxin beta receptor pathway reverses the disease.
Medical subject headings
- Receptors, Tumor Necrosis Factor
- Respiratory Insufficiency
- Shock, Septic