Persistent ulcerated necrobiosis lipoidica responding to treatment with cyclosporin.
case_report · Level V
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Abstract
We report two patients with severe ulcerated necrobiosis lipoidica (NL) who responded to cyclosporin. One patient had suffered persistent ulceration for a period of 7 years and the other had NL of recent onset. In both cases, ulceration healed completely after 4 months of therapy, and both patients have remained free of ulceration since discontinuing therapy. The possible mode of action of cyclosporin in the context of this debilitating disease is discussed.
Medical subject headings
- Cyclosporine
- Immunosuppressive Agents
- Leg Ulcer
- Necrobiosis Lipoidica