Synergistic effect of rapamycin and cyclosporine in prevention of acute kidney allograft rejection in the mouse.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 10586201.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The effect of rapamycin (RAPA) and cyclosporine A (CsA) monotherapy and combination therapy was examined in prevention of kidney allograft rejection in the mouse. Both drugs were administered orally for up to 14 days in BALB/c (H-2(d)) to C57BL/6 (H-2(b)) mice strong combination. Six groups were treated with RAPA and/or CsA. This study shows that concomitant therapy of RAPA and CsA produces strong synergistic interaction in prolonging renal allograft survival in mice when compared with monotherapy of RAPA or CsA.
Medical subject headings
- Cyclosporine
- Graft Rejection
- Immunosuppressive Agents
- Kidney Transplantation
- Sirolimus