Telomeres of polytene chromosomes in a ciliated protozoan terminate in duplex DNA loops.
basic_science · Level V
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- Record sourced from PubMed, PMID 10588723.
- Also identified by PMC identifier 24454.
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Abstract
The end of a telomeric DNA sequence isolated from a polytene chromosome of a hypotrichous ciliate folds back and hybridizes with downstream telomeric sequence to form a t loop that is stable in the absence of protein and DNA cross-linking. The single-stranded, telomeric DNA sequence at the end of a macronuclear molecule does not form a t loop but, instead, is complexed with a heterodimeric, telomere-binding protein. Thus, two mechanisms for capping the ends of DNA molecules are used in the same cell.
Medical subject headings
- Chromosomes
- DNA, Protozoan
- Oxytricha
- Telomere