Increased 8-oxo-dGTPase in the mitochondria of substantia nigral neurons in Parkinson's disease.
case_series · Level IV
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Abstract
There is growing evidence for the involvement of oxidative stress and mitochondrial respiratory failure in nigral neuronal death in Parkinson's disease (PD). We report increased immunoreactivity of 8-oxo-dGTPase (8-oxo-7, 8-dihydrodeoxyguanosine triphosphatase [hMTH1]), an enzyme known to play an important role in controlling spontaneous mutagenesis, and 8-oxo-7, 8-deoxyguanosine (8-oxo-dG) in the mitochondria of the substantia nigra of 6 PD patients. Our results suggest that hMTH1 might be a useful marker of oxidative stress and can be used to explore the relation between such oxidative stress and genomic instability.
Medical subject headings
- DNA Repair Enzymes
- Deoxyguanosine
- Mitochondria
- Neurons
- Parkinson Disease
- Phosphoric Monoester Hydrolases
- Substantia Nigra