Intracerebral hemorrhage outcome: apolipoprotein E genotype, hematoma, and edema volumes.
prospective_cohort · Level II
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Abstract
We investigated whether early hematoma or edema volumes could explain the adverse association between APOE epsilon4 and survival in intracerebral hemorrhage. Among 102 patients, epsilon4 carriers had a higher mortality rate than non-epsilon4 carriers (38 versus 24%, p = 0.05). Nonsurvivors had larger hematoma (75.5 cm3 versus 27.1 cm3, p<0.001) and edema volumes (37.5 cm3 versus 17.1 cm3, p<0.01), but these were not associated with epsilon4 after adjusting for race, age, and type of hemorrhage.
Medical subject headings
- Apolipoproteins E
- Brain Edema
- Cerebral Hemorrhage
- Genotype
- Hematoma