Evolution of shape complementarity and catalytic efficiency from a primordial antibody template.
basic_science · Level V
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Abstract
The crystal structure of an efficient Diels-Alder antibody catalyst at 1.9 angstrom resolution reveals almost perfect shape complementarity with its transition state analog. Comparison with highly related progesterone and Diels-Alderase antibodies that arose from the same primordial germ line template shows the relatively subtle mutational steps that were able to evolve both structural complementarity and catalytic efficiency.
Medical subject headings
- Antibodies, Catalytic
- Evolution, Molecular