Bone non-union after osteotomy in patients treated with methotrexate.
case_report · Level V
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Abstract
We describe 2 men with seronegative rheumatoid arthritis who presented non-union of bone after osteotomy of the tibia in one case and of a metatarsal bone in the second. Both patients were still being treated with oral low doses of methotrexate (MTX). After MTX was stopped, a prompt healing of the bone occurred. These observations suggest that MTX should be stopped temporarily in cases with delayed bone healing after surgery.
Medical subject headings
- Antirheumatic Agents
- Arthritis, Rheumatoid
- Bony Callus
- Methotrexate
- Osteotomy