Intravenous immunoglobulins as treatment of life threatening esophageal involvement in polymyositis and dermatomyositis.
case_report · Level V
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Abstract
Esophageal involvement is considered a major cause of morbidity and an indicator of poor prognosis in polymyositis (PM) and dermatomyositis (DM). We describe 3 patients with steroid resistant PM/DM with life threatening esophageal involvement, resulting in impossible oral feeding and enteral nutrition with a gastric tube. All patients had both dramatic and rapid improvement of all clinical manifestations after initiation of intravenous immunoglobulin (IVIG) therapy. Swallowing disorders completely disappeared after the second infusion of IVIG, which permitted normal oral feeding and ablation of the gastric tube. Our findings suggest IVIG should be considered the treatment of choice in such cases.
Medical subject headings
- Dermatomyositis
- Esophageal Diseases
- Immunoglobulins, Intravenous