A RhoA-derived peptide inhibits syncytium formation induced by respiratory syncytial virus and parainfluenza virus type 3.
basic_science · Level V
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- Record sourced from PubMed, PMID 10613821.
- Also identified by PMC identifier 7095870.
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Abstract
The fusion glycoproteins of human respiratory syncytial virus (RSV) and human parainfluenza virus type-3 (PIV-3) mediate virus entry and syncytium formation. Interaction between the fusion protein of RSV and RhoA, a small GTPase, facilitates virus-induced syncytium formation. We show here a RhoA-derived peptide inhibits RSV and syncytium formation induced by RSV and PIV-3, both in vitro by inhibition of cell-to-cell fusion and in vivo by reduction of peak titer by 2 log10 in RSV-infected mice. These findings indicate that the interaction between these two paramyxovirus fusion proteins and RhoA is an important target for new antiviral strategies.
Medical subject headings
- Giant Cells
- Parainfluenza Virus 3, Human
- Peptide Fragments
- Respiratory Syncytial Virus Infections
- Respiratory Syncytial Virus, Human
- rhoA GTP-Binding Protein