Severe hypercalcaemia in B-cell lymphoma: combined effects of PTH-rP, IL-6 and TNF.
case_report · Level V
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- Record sourced from PubMed, PMID 10621879.
- Also identified by PMC identifier 1741407.
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Abstract
Hypercalcaemia as the only manifestation of B-cell lymphoma is seen very rarely. Its pathophysiology is heterogenous and not well understood. We report a 73-year-old man who presented with severe hypercalcaemia before any signs of malignancy became evident. He was diagnosed with a B-cell lymphoma on bone marrow trephine biopsy. The hypercalcaemia was associated with high plasma concentrations of parathyroid-hormone-related protein, interleukin-6 and tumour necrosis factor. Our patient had markedly increased osteoclast and osteoblast activity as a result of synergistic effects between these factors, with consequent severe hypercalcaemia. This is the first reported example of such combined effects of these factors in humans.
Medical subject headings
- Hypercalcemia
- Interleukin-6
- Lymphoma, B-Cell
- Neoplasm Proteins
- Proteins
- Tumor Necrosis Factor-alpha