Accelerated hyperfractionated radiotherapy in 149 patients with glioblastoma multiforme.
retrospective_cohort · Level III
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Abstract
Between August 1986 and December 1997, 149 patients with glioblastoma were treated postoperatively with 1.5 Gy fractions three times daily to a total dose of 54 Gy with 4-h intervals. Median actuarial survival was 8.8 months. Survival was 31% at 12 months and 4% at 24 months. No severe acute toxicity occurred. Multivariate analysis revealed that only age < or = 60 years and lactate dehydrogenase levels < or = 240 U/l predicted significantly higher survival probabilities.
Medical subject headings
- Brain Neoplasms
- Glioblastoma