Cellular radiosensitivity of patients with papillary thyroid cancer.
basic_science · Level V
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Abstract
Cultured skin fibroblasts from patients with papillary (differentiated) thyroid carcinomas were compared to those from healthy subjects, ataxia telangiectasia (AT) homozygotes and AT heterozygotes for colony-forming ability after low dose-rate irradiation, and post-irradiation DNA synthesis as indicated by uptake of [3H]-thymidine. The cells from the cancer patients exhibited enhanced radiosensitivity (intermediate between normal and AT) and less than normal level of radioinduced inhibition of DNA synthesis.
Medical subject headings
- Carcinoma, Papillary
- Fibroblasts
- Radiation Tolerance
- Thyroid Neoplasms