DNA analysis of a transplanted cryopreserved meniscal allograft.
case_report · Level V
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Abstract
Meniscal transplantation is frequently performed in young patients with a single meniscal-deficient compartment as a result of previous total meniscectomy. Indications, operative techniques, and preservation of meniscal allografts have been studied extensively. In this study we compared the DNA profile of a meniscal allograft with that of the human recipient 1 year after transplantation. Applying techniques routinely used in forensic analysis, we were able to show that the DNA profile of the meniscal allograft was 95% identical to that of the human recipient. These findings indicate that 1 year after transplantation the meniscal allograft is nearly completely repopulated by host cells.
Medical subject headings
- Cartilage Diseases
- Collagen
- Cryopreservation
- DNA
- Menisci, Tibial
Anatomy
- knee
- tibia