Inverse relation between prostate-specific antigen and insulin-like growth factor-binding protein 3 in bone metastases and serum of patients with prostate cancer.
basic_science · Level V
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Abstract
The usual osteoblastic phenotype of metastatic prostate cancer is unexplained. Here we show that tissue and serum concentrations of prostate-specific antigen (PSA)-vary inversely with a substrate protein that binds a growth factor known to activate osteoblasts. These findings suggest that PSA may contribute to the osteoblastic phenotype, and could thus represent a new drug target devoid of antiandrogenic toxicity.
Medical subject headings
- Biomarkers, Tumor
- Bone Neoplasms
- Insulin-Like Growth Factor Binding Protein 3
- Prostate-Specific Antigen
- Prostatic Neoplasms