Sickle-cell disease not identified by newborn screening because of prior transfusion.
case_report · Level V
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- Record sourced from PubMed, PMID 10657834.
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Abstract
Erythrocyte transfusion can impair detection of sickle-cell disease, galactosemia, or biotinidase deficiency with newborn screening. We report on 4 infants with SCD in whom delayed diagnosis was associated with neonatal transfusion. In 2 cases, the initial newborn screening showed no hemoglobin S. In no case was the recommended screening >/=120 days from the last transfusion obtained. Two children had significant SCD-related morbidity before diagnosis.
Medical subject headings
- Anemia, Neonatal
- Anemia, Sickle Cell
- Blood Group Incompatibility
- Erythrocyte Transfusion
- Neonatal Screening