Molecular mechanisms of IgE regulation.
review · Level V
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- Record sourced from PubMed, PMID 10669540.
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Abstract
IgE antibody plays an important role in allergic diseases. IgE synthesis by B cells requires two signals. The first signal is delivered by the cytokines IL-4 or IL-13, which target the Cepsilon gene for switch recombination. The second signal is delivered by interaction of the B cell surface antigen CD40 with its ligand (CD40L) expressed on activated T cells. This activates deletional switch recombination. We review the molecular mechanisms of IL-4 and CD40 signaling that lead to IgE isotype switching and discuss the implications for intervening to abort or suppress the IgE antibody response.
Medical subject headings
- B-Lymphocytes
- Gene Rearrangement
- Immunoglobulin E