Possible paracrine growth of adenocarcinoma of the stomach induced by granulocyte colony stimulating factor produced by squamous cell carcinoma of the oesophagus.
case_report · Level V
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- Record sourced from PubMed, PMID 10673310.
- Also identified by PMC identifier 1727843.
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Abstract
Synchronous cancers of the oesophagus and stomach diagnosed in a patient showing pronounced leucocytosis were examined for production of granulocyte colony stimulating factor (G-CSF) and expression of G-CSF receptor. Whereas enzyme immunoassay of tissue extracts showed that the oesophageal carcinoma produced G-CSF, the gastric cancer did not. However, the gastric tumour showed G-CSF receptor expression on immunohistochemical examination of sections. These findings suggest that the oesophageal cancer promoted gastric cancer growth by paracrine mechanisms involving G-CSF.
Medical subject headings
- Adenocarcinoma
- Carcinoma, Squamous Cell
- Esophageal Neoplasms
- Neoplasms, Multiple Primary
- Stomach Neoplasms