Association of SWAP-70 with the B cell antigen receptor complex.
basic_science · Level V
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- Record sourced from PubMed, PMID 10681448.
- Also identified by PMC identifier 15774.
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Abstract
SWAP-70 is a component of an enzyme complex that recombines Ig switch regions in vitro. We report here the cloning of the human cDNA and its B lymphocyte-specific expression. Although its sequence contains three nuclear localization signals, in small resting B cells, SWAP-70 is mainly found in the cytoplasm. On stimulation, SWAP-70 translocates to the nucleus. In activated, class-switching B cell cultures, it is associated with membrane IgG, but not IgM. The membrane Ig association requires a functional pleckstrin homology domain and is controlled by the C terminus. We suggest that SWAP-70 is involved not only in nuclear events but also in signaling in B cell activation.
Medical subject headings
- DNA-Binding Proteins
- Guanine Nucleotide Exchange Factors
- Nuclear Proteins
- Receptors, Antigen, B-Cell