Patch granuloma annulare: clinicopathologic study of 6 patients.

Abstract

Granuloma annulare is a common skin disorder that usually presents with smooth papules arranged as annular plaques. Variants, such as disseminated, subcutaneous, and perforating granuloma annulare, have been described. The purpose of this study is to describe the clinical and histologic features of a distinct patch form of granuloma annulare. The clinical and histologic features of 6 patients with patch granuloma annulare were evaluated. Six women 27 to 72 years of age had patches on the extremities. Two patients also had a lesion on the trunk. Only one patient had annular patches. Histologic examination showed an interstitial infiltrate of lymphocytes and histiocytes with diffuse necrobiosis. Patch granuloma annulare is a distinct variant with rather subtle clinical and histologic features. A high index of suspicion both clinically and histologically aids in making the diagnosis.