Targeted toxins.
review · Level V
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- Record sourced from PubMed, PMID 10690507.
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Abstract
Targeted toxins, consisting of tumor-selective ligands coupled to polypeptide toxins, represent a new class of cancer therapeutics that kills malignant cells by inactivating cytosolic protein synthesis and inducing apoptosis. A number of these molecules have been produced under good manufacturing practice conditions and given systemically to patients with a variety of neoplasms. The promising results to date and the remaining pharmacological hurdles are discussed.
Medical subject headings
- Antineoplastic Agents
- Cytotoxins
- Immunotoxins
- Neoplasms