Cox-2 expression in retinoblastoma.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 10704568.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Cox-2, a prostaglandin synthase, is overexpressed in colorectal cancers and is involved in angiogenesis as well as in tumorigenesis. In this study, we investigate the expression of Cox-2 in retinoblastoma. Twenty-nine formalin-fixed retinoblastoma specimens were examined by the labeled-streptavidin-biotin method using anti-Cox-2 antibody. Cox-2 positive immunoreactions were observed in 28 (96%) of 29 retinoblastomas specimens. This preliminary study suggests the overexpression of Cox-2 in both differentiated and undifferentiated retinoblastoma and its possible role in tumorigenesis.
Medical subject headings
- Isoenzymes
- Peroxidases
- Prostaglandin-Endoperoxide Synthases
- Retinal Neoplasms
- Retinoblastoma