The retro-GCN4 leucine zipper sequence forms a stable three-dimensional structure.
basic_science · Level V
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- Record sourced from PubMed, PMID 10716989.
- Also identified by PMC identifier 15968.
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Abstract
The question of whether a protein whose natural sequence is inverted adopts a stable fold is still under debate. We have determined the 2. 1-A crystal structure of the retro-GCN4 leucine zipper. In contrast to the two-stranded helical coiled-coil GCN4 leucine zipper, the retro-leucine zipper formed a very stable, parallel four-helix bundle, which now lends itself to further structural and functional studies.
Medical subject headings
- DNA-Binding Proteins
- Fungal Proteins
- Leucine Zippers
- Protein Kinases
- Saccharomyces cerevisiae Proteins