Influenza A and B viruses expressing altered NS1 proteins: A vaccine approach.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 10725408.
- Also identified by PMC identifier 18238.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
We propose a rational approach to the generation of live viral vaccines: alteration of virally encoded type I IFN antagonists to attenuate virulence while retaining immunogenicity. We have explored this concept by using the influenza virus. Previously we have shown that the NS1 protein of influenza A virus possesses anti-IFN activity. We now present evidence that influenza A and B viruses encoding altered viral NS1 proteins are highly attenuated in the mouse host, yet provide protection from challenge with wild-type viruses.
Medical subject headings
- Influenza A virus
- Influenza B virus
- Influenza Vaccines
- Viral Nonstructural Proteins