Squamous cell carcinoma arising in Hailey-Hailey disease of the vulva.
case_report · Level V
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Abstract
A 61-year-old woman, who was known to have Hailey-Hailey disease, presented with increasing vulval soreness. Biopsy showed vulval intraepithelial neoplasia (VIN) 3 and subsequent histology from a vulvectomy specimen showed extensive VIN with early invasive squamous cell carcinoma. This may be another example of chronic inflammation of the vulval area leading to the development of squamous cell carcinoma. However, in this case, chronic human papillomavirus may also have played a part, leading to VIN and reactivation of the Hailey-Hailey disease. We can find no previous reports of squamous cell carcinoma developing in the setting of Hailey-Hailey disease.
Medical subject headings
- Carcinoma in Situ
- Carcinoma, Squamous Cell
- Pemphigus, Benign Familial
- Vulvar Diseases
- Vulvar Neoplasms