Benzodiazepine receptor binding in Huntington's disease: [11C]flumazenil uptake measured using positron emission tomography.
basic_science · Level V
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Abstract
We used positron emission tomography and [11C]flumazenil to analyze the benzodiazepine receptor binding in symptomatic and asymptomatic carriers of the Huntington's disease gene. We found an inverse relationship between [11C]flumazenil and [11C]raclopride binding in the putamen of symptomatic patients, and interpret this result as GABA receptor upregulation.
Medical subject headings
- Caudate Nucleus
- Flumazenil
- GABA Modulators
- Huntington Disease
- Putamen
- Receptors, GABA-A
- Tomography, Emission-Computed