Selective disruption of protein aggregation by cyclodextrin dimers.
basic_science · Level V
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- Record sourced from PubMed, PMID 10805768.
- Also identified by PMC identifier 25779.
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Abstract
Beta-cyclodextrin (CD) dimers (n = 11) were synthesized and tested against eight enzymes, seven of which were dimeric or tetrameric, for inhibitor activity. Initial screening showed that only L-lactate dehydrogenase and citrate synthase were inhibited but only by two specific CD dimers in which two beta-CDs were linked on the secondary face by a pyridine-2,6-dicarboxylic group. Further investigation suggested that these CD dimers inhibit the activity of L-lactate dehydrogenase and citrate synthase at least in part by disruption of protein-protein aggregation.
Medical subject headings
- Cyclodextrins
- Enzymes