Intratracheal recombinant human deoxyribonuclease in acute life-threatening asthma refractory to conventional treatment.
case_report · Level V
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Abstract
Recombinant human deoxyribonuclease (rhDNase) is a mucolytic agent used to relieve peripheral airway obstruction in patients with cystic fibrosis. We report dramatic sustained improvement following the intratracheal administration of rhDNase to a 3-yr-old boy with acute life-threatening asthma in whom 48 h of aggressive therapy had failed.
Medical subject headings
- Asthma
- Deoxyribonuclease I
- Expectorants