Hypersensitivity syndrome caused by amitriptyline administration.
case_report · Level V
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- Record sourced from PubMed, PMID 10824052.
- Also identified by PMC identifier 1741629.
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Abstract
Adverse cutaneous manifestations are among the most common side effects associated with psychotropic drugs. Skin reactions due to amitriptyline (a tricyclic antidepressant agent) include rashes and hypersensitivity reactions (for example, urticaria and photosensitivity) as well as hyperpigmentation. Hypersensitivity syndrome is a specific severe idiosyncratic reaction causing skin, liver, joint, and haematological abnormalities, which usually resolve after the discontinuation of the implicated drug. A case of a 24 year old woman who experienced hypersensitivity syndrome three weeks after the initiation of amitriptyline is reported.
Medical subject headings
- Amitriptyline
- Antidepressive Agents, Tricyclic
- Drug Eruptions
- Fever