Multiple differences in gene expression in regulatory Valpha 24Jalpha Q T cells from identical twins discordant for type I diabetes.
basic_science · Level V
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- Record sourced from PubMed, PMID 10840051.
- Also identified by PMC identifier 16559.
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Abstract
Quantitative and qualitative defects in CD1d-restricted T cells have been demonstrated in human and murine autoimmune diseases. To investigate the transcriptional consequences of T cell receptor activation in human Valpha24JalphaQ T cell clones, DNA microarrays were used to quantitate changes in mRNA levels after anti-CD3 stimulation of clones derived from identical twins discordant for type 1 diabetes and IL-4 secretion. Activation resulted in significant modulation of 226 transcripts in the IL-4 secreting clone and 86 in the IL-4-null clone. Only 28 of these genes were in common. The differences observed suggest both ineffective differentiation of diabetic Valpha24JalphaQ T cells and a role for invariant T cells in the recruitment and activation of cells from the myeloid lineage.
Medical subject headings
- Diabetes Mellitus, Type 1
- Gene Expression Regulation
- Immunoglobulin Variable Region
- Receptors, Antigen, T-Cell, alpha-beta
- T-Lymphocytes
- Twins