Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity.
basic_science · Level V
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- Record sourced from PubMed, PMID 10862788.
- Also identified by PMC identifier 378505.
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Abstract
The immune response to oxidized LDL (OxLDL) may play an important role in atherogenesis. Working with apoE-deficient mice, we isolated a panel of OxLDL-specific B-cell lines that secrete IgM Abs that specifically bind to oxidized phospholipids such as 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine (POVPC). These Abs block uptake of OxLDL by macrophages, recognize similar oxidation-specific epitopes on apoptotic cells, and are deposited in atherosclerotic lesions. The Abs were found to be structurally and functionally identical to classic "natural" T15 anti-PC Abs that are of B-1 cell origin and are reported to provide optimal protection from virulent pneumococcal infection. These findings suggest that there has been natural selection for B-1 cells secreting oxidation-specific/T15 antibodies, both for their role in natural immune defense and for housekeeping roles against oxidation-dependent neodeterminants in health and disease.
Medical subject headings
- Apoptosis
- Arteriosclerosis
- Autoantibodies
- B-Lymphocytes
- Immunoglobulin Idiotypes
- Lipoproteins, LDL