Injections of botulinum toxin A into the salivary glands improve sialorrhoea in amyotrophic lateral sclerosis.
case_series · Level IV
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- Record sourced from PubMed, PMID 10864618.
- Also identified by PMC identifier 1736996.
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Abstract
Sialorrhoea is a socially disabling problem in bulbar amyotrophic lateral sclerosis (ALS). Botulinum toxin A (BoNT/A) was injected into the salivary glands in five patients with bulbar ALS and sialorrhoea. The effect of BoNT/A was measured by the number of paper handkerchiefs used each day and by salivary gland scintigraphy. BoNT/A ameliorated sialorrhoea and quality of life without major adverse effects. BoNT/A may be a relatively safe and effective treatment for sialorrhoea in selected patients.
Medical subject headings
- Amyotrophic Lateral Sclerosis
- Botulinum Toxins, Type A
- Parotid Gland
- Sialorrhea