Current tuberculosis vaccine development.
review · Level V
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- Record sourced from PubMed, PMID 10875794.
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Abstract
Information derived from the complete genome sequence of Mycobacterium tuberculosis makes it possible to develop a range of new vaccine candidates. Strategies currently under investigation include construction of whole cell live attenuated mycobacterial vaccines, as well as the use of individual antigens delivered by a variety of subunit vaccination procedures. Fundamental questions associated with the rational design, preclinical testing, and future application of new tuberculosis vaccines are reviewed.
Medical subject headings
- BCG Vaccine
- Bacterial Vaccines
- Drug Design
- Mycobacterium tuberculosis
- Tuberculosis, Pulmonary