Kallikrein-kinin system activation in streptococcal toxic shock syndrome.
retrospective_cohort · Level III
Where this comes from
- Record sourced from PubMed, PMID 10880316.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
A retrospective analysis of 7 patients with streptococcal toxic shock revealed isolated prolongation of the activated partial thromboplastin time, which returned to normal during recovery. Levels of factor XII were reduced in 2 patients who had single factor assays performed, consistent with activation of the kallikrein-kinin system. We speculate that bradykinin release following activation of the kallikrein-kinin system in streptococcal toxic shock may underlie the features of pain, capillary leaking, and severe hypotension characteristic of this syndrome.
Medical subject headings
- Kallikreins
- Kinins
- Shock, Septic
- Streptococcal Infections
- Streptococcus pyogenes