Gluten-dependent diabetes-related and thyroid-related autoantibodies in patients with celiac disease.
prospective_cohort · Level II
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Abstract
Patients with celiac disease are at high risk of having autoimmune disorders. Moreover, untreated patients with celiac disease have been found to have a higher than expected prevalence of organ-specific autoantibodies. In a prospective study of 90 patients with celiac disease, we found that the prevalence of diabetes and thyroid-related serum antibodies was 11.1% and 14.4%, respectively. Like antiendomysium autoantibodies, these organ-specific antibodies seem to be gluten-dependent and tend to disappear during a gluten-free diet.
Medical subject headings
- Case-Control Studies
- Celiac Disease
- Celiac Disease/diet therapy
- Celiac Disease/epidemiology
- Child
- Comorbidity
- Diabetes Mellitus, Type 1
- Diabetes Mellitus, Type 1/epidemiology
- Diabetes Mellitus, Type 1/prevention & control
- Female
- Glutens
- Glutens/adverse effects
- Humans
- Italy
- Italy/epidemiology
- Male
- Prevalence
- Prospective Studies
- Thyroiditis, Autoimmune
- Thyroiditis, Autoimmune/epidemiology
- Thyroiditis, Autoimmune/prevention & control