Time course of oxidative stress after major burns.

Abstract

To evaluate oxidative stress resulting from major burns in humans. Prospective clinical study with control group. Mechanically ventilated adult patients admitted with more than 30% total burn surface area. 20 patients with a mean body surface burned area of 54%. The oxidative stress evaluation was based on measurements of trace elements, vitamins, antioxidant enzymatic activity and end-products of lipid peroxidation. During the first 5 days after injury burn patients exhibit a decrease in selenium and antioxidant vitamins (C, beta-carotene, lycopene) and an increase in lipid peroxidation products (TBARS). Our results suggest that major burn is associated with oxidative stress during the 5 days after the initial injury, as demonstrated by a simultaneous decrease in antioxidant vitamins and a large increase in TBARS.