Pregnancy outcome in carriers of fragile X.

Abstract

To evaluate pregnancy outcome in women who are carriers of fragile X. Cross-sectional case-control study. Department of Obstetrics and Gynaecology, Kuopio University Hospital, Finland. Sixty-three singleton pregnancies in carriers of fragile X who were referred for genetic counselling and prenatal diagnosis to Kuopio University Hospital. Logistic regression analysis was used to compare pregnancy outcome in women who are fragile X carrier with outcome of the general obstetric population. Carriers of fragile X often experienced more bleeding in late pregnancy than did the reference group. Otherwise, the course and outcome of pregnancy were comparable in both groups. Pregnancy outcome in women who are carriers of fragile X is favourable. There is no need to initiate special fetal monitoring because of the fragile X status of the woman.