Ischemia/reperfusion injury in microvascular surgery.
review · Level V
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- Record sourced from PubMed, PMID 11002326.
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Abstract
Ischemia/reperfusion injury is often the final and irreversible factor causing flap failure in microvascular surgery for head and neck defects. This paper begins with a detailed review of flap physiology and ischemia/reperfusion injury at the cellular level. Subsequently, the pharmacotherapeutic agents used clinically and experimentally to avoid or reverse ischemia/reperfusion injury are discussed. The goal of this review is to provide a framework for understanding the expanding body of literature relevant to ischemia/reperfusion injury in microvascular surgery.
Medical subject headings
- Microsurgery
- Reperfusion Injury
- Surgical Flaps
- Vascular Surgical Procedures