Increase of androgen-induced cell death and androgen receptor transactivation by BRCA1 in prostate cancer cells.
basic_science · Level V
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- Record sourced from PubMed, PMID 11016951.
- Also identified by PMC identifier 17187.
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Abstract
Although mutations of the breast cancer susceptibility gene 1 (BRCA1) may play important roles in breast and prostate cancers, the detailed mechanism linking the functions of BRCA1 to these two hormone-related tumors remains to be elucidated. Here, we report that BRCA1 interacts with androgen receptor (AR) and enhances AR target genes, such as p21((WAF1/CIP1)), that may result in the increase of androgen-induced cell death in prostate cancer cells. The BRCA1-enhanced AR transactivation can be further induced synergistically with AR coregulators, such as CBP, ARA55, and ARA70. Together, these data suggest that the BRCA1 may function as an AR coregulator and play positive roles in androgen-induced cell death in prostate cancer cells and other androgen/AR target organs.
Medical subject headings
- Androgens
- BRCA1 Protein
- Cell Death
- Prostatic Neoplasms
- Receptors, Androgen
- Transcriptional Activation