Treatment of latent tuberculosis infection in patients aged > or =35 years.
retrospective_cohort · Level III
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Abstract
Treating patients aged > or =35 years for tuberculosis infection has been controversial because of the hepatotoxic effects of isoniazid. A 2-year retrospective cohort study of outpatient medical records determined the completion rate in this age group and identified risk factors associated with isoniazid-associated hepatotoxicity. Isoniazid preventative therapy was well tolerated. However, toxicity occurred in women receiving concomitant medications and men who used alcohol.
Medical subject headings
- Isoniazid
- Tuberculosis, Pulmonary