Mizuo phenomenon observed by scanning laser ophthalmoscopy in a patient with Oguchi disease.

Abstract

To elucidate the origin of the abnormal fundus reflex in Oguchi disease. The ocular fundus of a 63-year-old woman who showed a homozygous arrestin 1147delA mutation was observed by scanning laser ophthalmoscopy with the use of an argon blue laser (wavelength, 488 nm), a helium-neon laser (633 nm), and an infrared laser (780 nm). Diffuse, fine, white particles, which do not exist in normal subjects, were clearly demonstrated only with the helium-neon laser. After 4-hour dark adaptation, the abnormal particles disappeared, but then they reappeared gradually during 30 minutes of light adaptation, in accordance with the golden metallic reflex. The white particles found by helium-neon laser could be the origin of the abnormal fundus reflex in Oguchi disease.